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Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.


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Record prescription levels for a common sleeping pill could be due to misuse by Brits wanting wild sex, experts warned today.

Zolpidem prescriptions this year hit the highest level since records began in 2018 — with 58,000 doses dished out in March.

For years Z-drugs like zolpidem, better known by its brand name Ambien, have been touted as a user-friendly alternative to older and notoriously addictive tranquillisers.

But up to one in 100 users of the drug will experience strange 'sleep-related behaviours' like sleepwalking or having sex without being fully aware, it is estimated.

Thousands of Ambien users have also shared their experiences of drug-induced sex on online forums labelling it the 'best sex they've ever had' and crediting the sleeping pill with allowing them to 'do things I would be too scared to do normally'.




Despite calls for a crackdown NHS data shows the number of prescriptions for powerful hypnotics have barely shifted over the past five years





For years Z-drugs like Zolpidem, better known as Ambien, have been touted as a user-friendly alternative to older and notoriously addictive tranquillisers. But up to one in 100 users of the drug will experience strange 'sleep-related behaviours' like sleepwalking or having sex without being fully aware while taking the drug, it is estimated

Experts however have warned the drug is 'strong medication' and must only be used by those experiencing 'distressing sleep behaviours'.

Nuno Albuquerque, Head of Treatment for the UK Addiction Treatment Group told MailOnline: 'It is absolutely plausible that the rise in prescriptions of zolpidem could be related to the outcome that for some, its use enhances a person's sex drive and/or sexual experiences.

'This of course won't be the case for everyone, but it is, anecdotally, something we have discussed with zolpidem clients during their treatment programmes.

'Our advice to anyone with regards to prescription drugs is to only take them when prescribed and only as prescribed.

'Zolpidem is a strong medication and should only be used in the short term and only by those who are experiencing distressing sleep behaviours.'

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